Kinesin-5: A Team Is Just the Sum of Its Parts.

Bi-objective Optimization for Just in Time Scheduling: Application to the Two-Stage Assembly Flow Shop Problem

This paper considers a two-stage assembly flow shop problem (TAFSP) where m machines are in the first stage and an assembly machine is in the second stage. The objective is to minimize a weighted sum of earliness and tardiness time for n available jobs. JIT seeks to identify and eliminate waste components including over production, waiting time, transportation, inventory, movement and defective...

The Knowledge Translation Complexity Network (KTCN) Model: The Whole Is Greater Than the Sum of the Parts - A Response to Recent Commentaries

Downregulation of Kinesin Spindle Protein Inhibits Proliferation, Induces Apoptosis and Increases Chemosensitivity in Hepatocellular Carcinoma Cells

Background: Kinesin spindle protein (KSP) plays a critical role in mitosis. Inhibition of KSP function leads to cell cycle arrest at mitosis and ultimately to cell death. The aim of this study was to suppress KSP expression by specific small-interfering RNA (siRNA) in Hep3B cells and evaluate its anti-tumor activity. Methods: Three siRNA targeting KSP (KSP-siRNA #1-3) and one mismatched-siRNA (...

Directional switching of the kinesin Cin8 through motor coupling.

Kinesin motor proteins are thought to move exclusively in either one or the other direction along microtubules. Proteins of the kinesin-5 family are tetrameric microtubule cross-linking motors important for cell division and differentiation in various organisms. Kinesin-5 motors are considered to be plus-end-directed. However, here we found that purified kinesin-5 Cin8 from budding yeast could ...

Just chromatic exellence in fuzzy graphs

A fuzzy graph is a symmetric binary fuzzy relation on a fuzzy subset. The concept of fuzzy sets and fuzzy relations was introduced by L.A.Zadeh in 1965cite{zl} and further studiedcite{ka}. It was Rosenfeldcite{ra} who considered fuzzy relations on fuzzy sets and developed the theory of fuzzy graphs in 1975. The concepts of fuzzy trees, blocks, bridges and cut nodes in fuzzy graph has been studi...